B-hGPR75 mice

C57BL/6JNifdc-Gpr75tm1(GPR75)Bcgen/Bcgen • 112305

B-hGPR75 mice

Catalog Number: 112305
Strain Name: C57BL/6JNifdc-Gpr75tm1(GPR75)Bcgen/Bcgen
Strain Background: C57BL/6JNifdc
NCBI gene ID: 10936 (Human)
Aliases: GPRchr2; WI31133
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B-hGPR75 mice

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  • Targeting strategy
  • Phenotypic analysis

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    发表文章

      Targeting strategy

      Gene targeting strategy for B-hGPR75 mice. The exons 2 of mouse Gpr75 gene that encodes the full-length protein was replaced by human GPR75 exons 2 in B-hGPR75 mice.

      mRNA expression analysis
      Strain specific analysis of GPR75 gene expression in wild-type C57BL/6 mice and B-hGPR75 mice by RT-PCR. Mouse GPR75 mRNA was detectable in brain of wild-type C57BL/6 mice, GPR75 mRNA was detectable in brain of wild-type C57BL/6 mice and homozygous B-hGPR75 mice (H/H) due to the high genetic similarity, and we sequenced and confirmed that the replaced region of homozygous B-hGPR75 mice (H/H) is the human GPR75 sequence.
      * When publishing results obtained using this animal model, please acknowledge the source as follows: The animal model [B-hGPR75 mice] (Cat# 112305) was purchased from Biocytogen.
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