Description
The Low Density Lipoprotein (LDL) Receptor is a cell-surface receptor presented in clathrin-coated pits that mediates the endocytosis of LDL, the major cholesterol-carrying lipoprotein of plasma. Loss of Ldlr function leads to accumulation of excess LDL in the blood, leading to elevated serum cholesterol, especially when fed a high fat diet, which makes Ldlr knockout rat a good model for studying atherosclerosis, familial hypercholesterolemia. This rat can be used to support research in many areas including diabetes and obesity research, cardiovascular research, metabolism research etc.
Model validation and analysis
Homozygous Ldlrtm1/Bcgen rats demonstrate significantly elevated serum cholesterol levels at 4 months of age.
* When publishing results obtained using this animal model, please acknowledge the source as follows: The animal model [B-Ldlr KO rats] (Cat# 210506) was purchased from Biocytogen.
